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Researchers have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer. A professor of pediatrics-developmental biology and an assistant professor of molecular, cellular, and developmental biology have shown the importance of the H3K36 methylation process in regulating plasticity and regeneration in intestinal cells.

Interferometers, devices that can modulate aspects of light, play the important role of modulating and switching light signals in fiber-optic communications networks and are frequently used for gas sensing and optical computing. Now, applied physicists have invented a new type of interferometer that allows precise control of light's frequency, intensity and mode in one compact package.

By watching the ebb and flow of the brain's chemical signals, researchers are beginning to disentangle the molecular mechanisms underlying the intrinsic motivation to learn. In a new study of zebra finches, researchers show that a hit a dopamine tells baby birds when their song practice is paying off. The findings suggest that dopamine acts like an internal 'compass' to steer their learning when external incentives are absent.

In 2010, a researcher was pouring over research data when he discovered something he thought was odd: His data showed that at 6 months of age, formula-fed babies born of mothers who were categorized as medically obese weighed about 5% units less fat than breastfed babies in the same dataset. That discovery struck him as unusual and led him on a research journey to better understand breast milk. Now, he's studying the connections between maternal gestational diabetes, breastfeeding and infant health.

Even with significant expansion in the global market for antibodies used in clinical care and research, scientists recognize that there is still untapped potential for finding new antibodies. Many proteins group together in what are called protein complexes to carry out biological functions. The traditional method of generating antibodies by immunizing animals struggles to make antibodies related to these protein complexes. Scientists have now demonstrated that fusing protein complexes together adds stability during immunization and enables antibody generation.

A study finds NBA teams that hired more analytics staff, and invested more in data analysis, tended to win more games.

Researchers explored how the characteristics of communication networks in groups (i.e., density and centralization) affected the development of shared social identity and, as a result, group performance. The study's findings can help managers and other business leaders develop strategies to enhance the performance of their teams.

Exposure to antibiotics during a key developmental window in infancy can stunt growth of insulin-producing cells in the pancreas and may boost risk of diabetes later in life, new research in mice suggests. The study also pinpoints specific microorganisms that may help those critical cells proliferate.

Fossil-fuel plants are increasingly being forced to stop and start production in response to changes in output from renewables. In a new study, researchers developed a dynamic competitive benchmark that accounts for start-up costs and other unit-level operating constraints. They apply their framework to Western Australia, a setting where rooftop solar capacity more than doubled between 2014 to 2018 to world-leading rooftop solar penetration rates. The study found that the large-scale expansion of rooftop solar capacity can lead to increases in the collective profitability of fossil fuel plants because competition softens at sunset--- plants displaced by solar during the day must incur start-up costs to compete in the evening.

A flower-shaped structure only a few micrometres in size made of a nickel-iron alloy can concentrate and locally enhance magnetic fields. The size of the effect can be controlled by varying the geometry and number of 'petals'. This magnetic metamaterial developed by Dr Anna Palau's group at the Institut de Ciencia de Materials de Barcelona (ICMAB) in collaboration with her partners of the CHIST-ERA MetaMagIC project, has now been studied at BESSY II in collaboration with Dr Sergio Valencia. Such a device can be used to increase the sensitivity of magnetic sensors, to reduce the energy required for creating local magnetic fields, but also, at the PEEM experimental station, to study samples under much higher magnetic fields than currently possible.

For human health, prematurely aging cells are a big problem. When a cell ages and stops growing, its function changes, which can cause or worsen cardiovascular disease, Alzheimer's disease and other chronic diseases. But these cells are also like needles in a haystack, difficult to identify by traditional scientific measures.

How is organic matter transported from productive coastal areas to the open ocean? Researchers have now shown that eddies play a crucial role in this process. The swirling currents contain large amounts of energy-rich and essential fat molecules (essential lipids), which play a key role in marine food webs and the carbon cycle.

This research comes as many mosquito-borne viruses are spreading rapidly.

A drug typically prescribed for arthritis halts brain-damaging seizures in mice that have a condition like epilepsy, according to researchers. If the drug proves viable for human patients, it would be the first to provide lasting relief from seizures even after they stopped taking it.

New research offers unprecedented insight into how an enigmatic enzyme, known as CDK7, drives the cell cycle and cell proliferation.

Mothers experience major metabolic adaptations during pregnancy and lactation to support the development and growth of the new life. Although many metabolic changes have been studied, body temperature regulation and environmental temperature preference during and after pregnancy remain poorly understood. Researchers show that postpartum female mice develop new environmental temperature preferences and reveal brain changes mediating these changes.

Scientists have discovered a promising way to trigger immune responses against certain tumors, using a lupus-related antibody that can slip, undetected, into 'cold' tumors and flip on an immune response that has been turned off by cancer. The research offers new findings that could help improve therapies for glioblastoma and other aggressive cancers that are difficult to treat.

Researchers presented advances shaping the world of forensics, from research that could improve how forensic scientists estimate a person's age at death, to technology demos of CSIxR -- a virtual reality (VR) application that simulates crime scenes scenarios to train crime scene investigators (CSIs).

Early animal studies show that a single vaccine could protect the recipient from different variants of the coronaviruses that cause COVID-19, the flu and the common cold. In addition to creating antibodies that target a specific region of the spike protein that doesn't mutate, the vaccine removes the sugar coat from the virus that allows it to hide in the body.

Plastic is everywhere in our daily lives. And much of what we use, such as cutting boards, clothes and cleaning sponges, can expose us to tiny, micrometer-wide plastic particles called microplastics. Now, chewing gum could be added to the list. In a pilot study, researchers found that chewing gum can release hundreds to thousands of microplastics per piece into saliva and potentially be ingested.

Deep below the Earth's surface, rock and mineral formations lay hidden with a secret brilliance. Under a black light, the chemicals fossilized within shine in brilliant hues of pink, blue and green. Scientists are using these fluorescent features to understand how the caves formed and the conditions for supporting life in extreme, and even extraterrestrial, environments.

The condition of the grass on a golf course can drastically skew the chances of a winning putt regardless of a player's skill. Now, a coating that soaks up water molecules could slow the roll of a golf ball on a lightning-fast, dry course and speed it up on a sluggish, wet course without interfering with the ball when it's airborne.

Tiny fragments of plastic have become ubiquitous in our environment and our bodies. Higher exposure to these microplastics, which can be inadvertently consumed or inhaled, is associated with a heightened prevalence of chronic noncommunicable diseases, according to new research.

In addition to causing several types of cancer, human papillomavirus (HPV) appears to bring a significantly increased risk of heart disease and coronary artery disease, according to a new study.

Whether it's an early morning jog, or a touch of Tai Chi, groundbreaking research shows that any form of exercise can significantly boost brain function and memory across children, adults, and older adults.

Crashes on electric scooters are mostly due to the behavior of the riders, with one-handed steering and riding in a group being some of the largest risk factors. The researchers are also concerned about riders who deliberately crash or cause dangerous situations when riding, a phenomenon that seems to be specific to electric scooters.

A new study has uncovered evidence of far-reaching ecosystem consequences following the disappearance of Great white sharks (Carcharodon carcharias) from False Bay, South Africa. The research spans over two decades and documents cascading ecological disruptions, underscoring the crucial role apex predators play in maintaining ocean health.

Life needs sufficient phosphorus. However, the element is scarce, not only today but also at the time of the origin of life. So where was there sufficient phosphorus four billion years ago for life to emerge? A team of origin-of-life researchers has an answer.

An adult brain affected by attention deficit disorder with or without hyperactivity (ADHD) presents modifications similar to those observed in individuals suffering from dementia. These are the findings of a study which shows that, compared with healthy individuals, patients with an ADHD diagnosis have more iron in certain regions of their brain along with higher levels of neurofilaments[1] (NfL) in their blood. These markers have been consistently reported to be characteristic of old age-related dementias such as Alzheimer's disease and can be measured in its early stages. The study confirms that ADHD may be linked to an increased risk of developing dementia later in life and it provides first evidence for a neurological mechanism possibly involved.

The study of elementary particles and forces is of central importance to our understanding of the universe. Now a team of physicists shows how an unconventional type of quantum computer opens a new door to the world of elementary particles.

An algorithm that learned from tens of thousands of nutrition prescriptions for premature babies could reduce medical errors and better identify what nutrients the smallest patients need.

Researchers have developed a highly accurate land cover map for Siberia, providing insights into climate change and predictions. Using advanced machine learning techniques and existing multiple land cover maps, they were able to address the significant discrepancies found in the previous datasets. Being one of the world's most climate-sensitive regions, Siberia's newly developed map marks a breakthrough, providing critical details crucial for understanding the region's extreme environmental changes.

Enzymes originally evolved in high-temperature environments and later adapted to lower temperatures as Earth cooled. Scientists discovered that a key shift in enzyme function occurred over evolutionary time due to amino acid changes distant from the active site. These mutations lowered activation energy, enhancing catalytic efficiency at low temperatures. Their findings highlight how global cooling events influenced enzyme evolution.

Obesity prevention strategies often focus on diet, but eating behaviors also play a key role. In a recent study, researchers from Japan investigated factors influencing meal duration, including sex differences, chewing patterns, and rhythmic cues. Their findings suggest that eating more slowly -- by increasing chews per bite or using slow rhythmic cues -- may help reduce food intake. These insights could inform practical, low-cost obesity prevention strategies by promoting slower eating habits in daily life.

Delayed and disorderly energy transitions will threaten economic and financial stability whilst also increasing the economic risks from climate change, according to a new study. Conversely, transitions that are started sooner are likely to be more orderly and economically beneficial.

This a robot can walk, without electronics, and only with the addition of a cartridge of compressed gas, right off the 3D-printer. It can also be printed in one go, from one material.

Researchers have determined that six gas valves provide the best protection against plasma disruptions in SPARC, a next-generation, experimental fusion system. By refining the setup for the fusion vessel's massive gas injection system, researchers are ensuring that disruptions -- sudden jets of plasma that can damage the fusion vessel's inner walls -- are controlled efficiently, paving the way for safer, more robust fusion power plants.

What goes through your mind when someone asks 'Did you see that?' A study shows that children and adults process ambiguous information like 'that' differently. While children focus more on the literal meaning, adults use multiple cues to grasp the speaker's intent. Researchers hope their findings could aid dialogue robot development and improve support systems for individuals with communication difficulties.

Engineers have derived potent new antibiotics from a frog's secretions. The new molecules demonstrated capabilities on par with existing last-resort antibiotics, without harming human cells or beneficial gut bacteria.

Researchers have found a potential new way to slow the progression of lung fibrosis and other fibrotic diseases by inhibiting the expression or function of Piezo2, a receptor that senses mechanical forces in tissues including stress, strain, and stiffness. The new study sheds light on the underlying mechanisms of pulmonary fibrotic diseases and identifies potential new targets and options for therapy to improve patients' outcomes.

Insecticides may help growers hoping to protect their crops from harmful insects, but they also may contribute to a larger amount of some weeds, according to a new study.

Researchers wondered if there was a more ethical way to enjoy foie gras, so they created a process to replicate the dish without force-feeding ducks and geese beyond their normal diets. They treated the fat with the bird's own lipases, mimicking the activities that occur naturally in the duck's body, and the resultant foie gras looked correct with noninvasive laser microscopy. The team confirmed the physical properties with stress-deformation tests and found that the treated foie gras had a similar mouthfeel to the original.

Researchers examine the properties of several dairy-free butter alternatives inside one of the region's most well-known snacks: Scottish shortbread. The group tested the alternatives in their lab, selecting three types of vegan butter substitutes with different levels of fat and comparing their consistencies and responses to heat. The vegan alternative with the highest fat content behaved like butter when baked and yielded the most positive feedback in taste testing. Butter typically has a fat content around 80%, and the group recommends choosing a vegan butter with a similar consistency.

The pathogen C. diff -- the most common cause of health care-associated infectious diarrhea -- can use a compound that kills the human gut's resident microbes to survive and grow, giving it a competitive advantage in the infected gut. A team has discovered how C. diff (Clostridioides difficile) converts the poisonous compound 4-thiouracil, which could come from foods like broccoli, into a usable nutrient. Their findings increase understanding of the molecular drivers of C. diff infection and point to novel therapeutic strategies.

Pro-environmental behavior increases among school students who participate in insect-related citizen science projects, according to new research.

A study has demonstrated the high accuracy of plasma p-tau217 as a blood-based biomarker for detecting abnormal brain beta-amyloid pathology, a hallmark of Alzheimer's disease.

Scientists investigated whether email interventions informed by behavioral science could help teachers help students learn math.

Researchers have developed an innovative sensing system that restores the missing tactile feedback in minimally invasive surgery (MIS), enhancing precision, ease of use, and safety. The new 'off-the-jaw' system integrates force and angle sensors into the handle of laparoscopic tools, providing surgeons with real-time measurements of grasping forces and insights into tissue stiffness and thickness.

The success of in vitro fertilization depends on many factors, one of which is sperm viability. A recent study documents a new way to select viable sperm and prolong their viability in the laboratory, reducing one source of variability during the process.

A storm, even once it has passed, can leave traces in the ocean that last for thousands of years. These consist of sediment layers composed of coarse particles, which are different from the finer sediments associated with good weather. In the Caribbean, an international research team has now examined such sediments using a 30 m long core from a 'blue hole' offshore Belize. The analysis shows that over the past 5,700 years, the frequency of tropical storms and hurricanes in the region has steadily increased. For the 21st century, the research team predicts a significant rise in regional storm frequency as a result of climate change.

The longest organic molecules identified to date on Mars have recently been detected. These long carbon chains, containing up to 12 consecutive carbon atoms, could exhibit features similar to the fatty acids produced on Earth by biological activity. The lack of geological activity and the cold, arid climate on Mars have helped preserve this invaluable organic matter in a clay-rich sample for the past 3.7 billion years. It therefore dates from the period during which life first emerged on Earth.

Mathematicians studied the flow of human crowds and developed a way to predict when pedestrian paths will transition from orderly to entangled. Their findings may help inform the design of public spaces that promote safe and efficient thoroughfares.

A team of researchers has developed a new tool designed to revolutionize hardware troubleshooting, with the help of 3D phone scans.

Researchers have discovered that chimpanzees living in Gombe Stream National Park in Tanzania employ a degree of engineering when making their tools, deliberately choosing plants that provide materials that produce more flexible tools for termite fishing.

In most high-income countries around the world, the number of avoidable mortalities is going down. But in the United States, avoidable deaths have been on the rise for more than a decade, according to a new study by researchers who examined mortality trends across U.S. states and 40 high-income countries.

Researchers developed olfactory tests -- in which participants sniff odor labels that have been placed on a card -- to assess people's ability to discriminate, identify and remember odors. They found that participants could successfully take the test at home and that older adults with cognitive impairment scored lower on the test than cognitively normal adults.

Maintaining a healthy diet rich in plant-based foods, with low to moderate intake of healthy animal-based foods and lower intake of ultra-processed foods, was linked to a higher likelihood of healthy aging -- defined as reaching age 70 free of major chronic diseases and with cognitive, physical, and mental health maintained, according to a new study. The study is among the first to examine multiple dietary patterns in midlife in relation to overall healthy aging.

Investigators have developed a long-acting contraceptive implant that can be delivered through tiny needles to minimize patient discomfort and increase the likelihood of medication use. Their findings in preclinical models provide the technological basis to develop self-administrable contraceptive shots that could mimic the long-term drug release of surgically implanted devices.

Researchers have developed a new material that, by harnessing the power of sunlight, can clear water of dangerous pollutants.

A new model suggests that timber production in Minnesota could decrease by half as windstorms intensify with climate change.