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Researchers have revealed that so-called “junk DNA” contains powerful switches that help control brain cells linked to Alzheimer’s disease. By experimentally testing nearly 1,000 DNA switches in human astrocytes, scientists identified around 150 that truly influence gene activity—many tied to known Alzheimer’s risk genes. The findings help explain why many disease-linked genetic changes sit outside genes themselves. The resulting dataset is now being used to train AI systems to predict gene control more accurately.

In a rare and historic achievement, Children’s Hospital Colorado successfully completed its first dual heart and liver transplant in a pediatric patient. The life-saving surgery was performed on 11-year-old Gracie Greenlaw, whose congenital heart condition eventually led to liver failure. Dozens of specialists worked together for years to prepare for a moment like this, executing a complex, 16-hour operation. Now months later, Gracie is home, in school, and thriving.

After injury, the visual system can recover by growing new neural connections rather than replacing lost cells. Researchers found that surviving eye cells formed extra branches that restored communication with the brain. These new pathways worked much like the originals. The repair process, however, was slower or incomplete in females, pointing to important biological differences in recovery.

New research reveals when glaciers around the world will vanish and why every fraction of a degree of warming could decide their fate.

Firefighter turnout gear is designed to shield first responders from extreme heat and danger, but new research suggests it may also introduce chemical exposures. A U.S. study found that brominated flame retardants are present across multiple layers of firefighter gear, including newer equipment marketed as PFAS-free. In some cases, these chemicals appeared at higher levels than the substances they were meant to replace.

Scientists have discovered that T cell receptors activate through a hidden spring-like motion that had never been seen before. This breakthrough may help explain why immunotherapy works for some cancers and how it could be improved for others.

Spending a few hours a week helping others may slow the aging of the brain. Researchers found that both formal volunteering and informal acts, like helping neighbors or relatives, were linked to noticeably slower cognitive decline over time. The benefits added up year after year and didn’t require a huge time commitment. Even modest, everyday helping packed a powerful mental payoff.

Long before whales and sharks, enormous marine reptiles dominated the oceans with unmatched power. Scientists have reconstructed a 130-million-year-old marine ecosystem from Colombia and found predators operating at a food-chain level higher than any seen today. The ancient seas were bursting with life, from giant reptiles to rich invertebrate communities. This extreme complexity reveals how intense competition helped drive the evolution of modern marine ecosystems.

Cosmic “touchdown airbursts” — explosions of comets or asteroids above Earth’s surface — may be far more common and destructive than previously thought, according to new research. Unlike crater-forming impacts, these events unleash extreme heat and pressure without leaving obvious scars, making them harder to detect.

Gravitational waves from black holes may soon reveal where dark matter is hiding. A new model shows how dark matter surrounding massive black holes leaves detectable fingerprints in the waves recorded by future space observatories.

A small tweak to mitochondrial energy production led to big gains in health and longevity. Mice engineered to boost a protein that helps mitochondria work more efficiently lived longer and showed better metabolism, stronger muscles, and healthier fat tissue. Their cells produced more energy while dialing down oxidative stress and inflammation tied to aging. The results hint that improving cellular power output could help slow the aging process itself.

Astronomers have detected spacetime itself being dragged and twisted by a spinning black hole for the first time. The discovery, seen during a star’s violent destruction, confirms a prediction made over 100 years ago and reveals new clues about how black holes spin and launch jets.

A new bioluminescent tool allows neurons to glow on their own, letting scientists track brain activity without harmful lasers or fading signals. The advance makes it possible to watch individual brain cells fire for hours, offering a clearer, deeper look at how the brain works.

Researchers announced over 70 new species in a single year, including bizarre insects, ancient dinosaurs, rare mammals, and deep-river fish. Many were found not in the wild, but in museum collections, proving that major discoveries can still be hiding in plain sight.

Much of the western U.S. is overdue for wildfire, with decades of suppression allowing fuel to build up across millions of hectares. Researchers estimate that 74% of the region is in a fire deficit, meaning far more land needs to burn to restore healthy forest conditions. Catching up would require an unprecedented amount of controlled and managed fire.

Researchers have uncovered that the body uses different molecular systems to sense cold in the skin versus internal organs. This explains why surface chills feel very different from cold experienced deep inside the body.

AI tools designed to diagnose cancer from tissue samples are quietly learning more than just disease patterns. New research shows these systems can infer patient demographics from pathology slides, leading to biased results for certain groups. The bias stems from how the models are trained and the data they see, not just from missing samples. Researchers also demonstrated a way to significantly reduce these disparities.

Researchers have identified a previously overlooked protein that helps regulate appetite and energy use in the body. This “helper” protein supports a key system that decides whether the body burns energy or stores it, and when it does not function properly, appetite signals can weaken.

Researchers have shown that quantum signals can be sent from Earth up to satellites, not just down from space as previously believed. This breakthrough could make global quantum networks far more powerful, affordable, and practical.

Traces of opium found inside an ancient alabaster vase suggest drug use was common in ancient Egypt, not rare or accidental. The discovery raises the possibility that King Tut’s famous jars once held opiates valued enough to be buried with pharaohs—and stolen by tomb raiders.

A long-standing physics mystery has been solved with the discovery of emergent photon-like behavior inside a strange quantum material. The finding confirms a true 3D quantum spin liquid and unlocks a new way to study deeply entangled matter.

More than 20% of young adults say they use cannabis or alcohol to fall asleep, with cannabis leading by a wide margin. Researchers warn this strategy can backfire, disrupting sleep quality and increasing the risk of long-term sleep and substance-use problems.

A missing brain molecule may be disrupting neural wiring in Down syndrome, according to new research. Replacing it in adult mice rewired brain circuits and improved brain flexibility, challenging the idea that treatment must happen before birth.

After a decade of painstaking measurements, scientists have delivered a major plot twist in particle physics: a long-hypothesized “mystery particle” likely doesn’t exist. Using the MicroBooNE experiment at Fermilab, researchers analyzed neutrinos from two powerful beams and found no evidence for a sterile neutrino, ruling it out with 95% certainty.

California researchers are preparing for the possible return of the New World screwworm, a parasitic fly that feeds on living flesh and once devastated U.S. livestock. By monitoring traps and educating veterinarians and farmers, they hope to stop the pest before it gains a foothold.

A rare tick-borne allergy linked to red meat has now been confirmed as deadly for the first time. A healthy New Jersey man collapsed and died hours after eating beef, with later testing revealing a severe allergic reaction tied to alpha-gal, a sugar spread by Lone Star tick bites. Symptoms often appear hours later, making the condition easy to miss. Researchers warn that growing tick populations could put more people at risk.

Ramanujan’s elegant formulas for calculating pi, developed more than a century ago, have unexpectedly resurfaced at the heart of modern physics. Researchers at IISc discovered that the same mathematical structures behind these formulas also describe real-world phenomena like turbulence, percolation, and even black holes. What once seemed like pure mathematics now appears deeply intertwined with the physical laws governing the universe.

A museum visit sparked a revelation when a Roman glass cup was turned around and its overlooked markings came into focus. These symbols, once dismissed as decoration, appear to be workshop identifiers used by teams of skilled artisans. The findings challenge centuries of assumptions about how Roman glass was made. They also restore identity and agency to the anonymous makers behind these stunning objects.

Kimchi may do far more than add flavor to meals—it could help fine-tune the human immune system. A clinical study using advanced single-cell genetic analysis found that regular kimchi consumption strengthens immune defenses while preventing harmful overreactions. Researchers observed improved activity in key immune cells, with effects varying depending on fermentation methods.

Scientists at Northern Arizona University are developing a promising new way to detect Alzheimer’s disease earlier than ever before—by tracking how the brain uses sugar. Using tiny particles in the blood called microvesicles, researchers may soon be able to gather brain-specific information without invasive procedures. If successful, this approach could transform Alzheimer’s diagnosis, monitoring, and even prevention, much like how doctors manage heart disease today.

A mysterious cloud of ultra-hot dust around Kappa Tucanae A may finally have an explanation: a hidden companion star. The star’s extreme orbit carries it straight through the dust zone, strongly suggesting it plays a key role in keeping the dust alive. This finding could help astronomers untangle one of the biggest challenges in imaging Earth-like exoplanets. It also opens the door to discovering similar hidden companions around other stars.

Researchers used miniature human brains grown in the lab to uncover why certain genetic mutations lead to abnormally small brains. Changes in actin disrupted the orientation of early brain cell divisions, causing crucial progenitor cells to disappear too soon. This reduced the brain’s ability to grow normally. The work offers a clear cellular explanation for microcephaly linked to Baraitser-Winter syndrome.

Over 8,000 years ago, early farming communities in northern Mesopotamia were already thinking mathematically—long before numbers were written down. By closely studying Halafian pottery, researchers uncovered floral and plant designs arranged with precise symmetry and numerical patterns, revealing a surprisingly advanced sense of geometry.

Scientists have digitally reconstructed the face of a 1.5-million-year-old Homo erectus fossil from Ethiopia, uncovering an unexpectedly primitive appearance. While its braincase fits with classic Homo erectus, the face and teeth resemble much older human ancestors. This discovery challenges long-held ideas about where and how Homo erectus evolved. It also hints at a complex web of migrations and possible mixing between early human species.

People think online platforms are overflowing with toxic and misleading content, but the reality is far calmer. A small group of highly active users creates most of the harm, while the majority remain relatively civil. Still, many Americans assume the worst about each other because of this imbalance. Correcting that belief can noticeably improve how people feel about society.

Cells may generate their own electrical signals through microscopic membrane motions. Researchers show that active molecular processes can create voltage spikes similar to those used by neurons. These signals could help drive ion transport and explain key biological functions. The work may also guide the design of intelligent, bio-inspired materials.

A newly developed AI can predict which diseases specific genetic mutations are likely to cause, not just whether they are harmful. The breakthrough could speed up diagnoses and open new paths for personalized treatment.

Cases of colorectal cancer in younger adults are climbing worldwide, driven by lifestyle changes and inherited genetic risks. Diet, obesity, and lack of early screening are playing a major role in this shift. New genetic tests offer hope for earlier detection, but access and awareness lag behind. Health experts say urgent action is needed to reverse the trend.

A new theory proposes that the universe’s fundamental forces and particle properties may arise from the geometry of hidden extra dimensions. These dimensions could twist and evolve over time, forming stable structures that generate mass and symmetry breaking on their own. The approach may even explain cosmic expansion and predict a new particle. It hints at a universe built entirely from geometry.

Scientists are uncovering a surprising way to influence bacteria—not by killing them, but by changing how they communicate. Researchers studying oral bacteria found that disrupting chemical signals used in bacterial “conversations” can shift dental plaque toward healthier, less harmful communities. The discovery could open the door to new treatments that prevent disease by maintaining a balanced microbiome rather than wiping bacteria out entirely.

Physicists have found a clever way to detect the elusive Unruh effect without extreme accelerations. By using atoms that emit light cooperatively between mirrors, acceleration subtly shifts when a powerful light burst appears. That early flash acts like a timestamped signature of the effect. The method could make once-theoretical physics experimentally reachable.

Consciousness evolved in stages, starting with basic survival responses like pain and alarm, then expanding into focused awareness and self-reflection. These layers help organisms avoid danger, learn from the environment, and coordinate socially. Surprisingly, birds show many of these same traits, from subjective perception to basic self-awareness. This suggests consciousness is far older and more widespread than once believed.

Around 1,000 years ago, a major climate shift reshaped rainfall across the South Pacific, making western islands like Samoa and Tonga drier while eastern islands such as Tahiti became increasingly wet. New evidence from plant waxes preserved in island sediments shows this change coincided with the final major wave of Polynesian expansion eastward. As freshwater became scarcer in the west and more abundant in the east, people may have been pushed to migrate, effectively “chasing the rain” across vast stretches of ocean.

Giant mosasaurs, once thought to be strictly ocean-dwelling predators, may have spent their final chapter prowling freshwater rivers alongside dinosaurs and crocodiles. A massive tooth found in North Dakota, analyzed using chemical isotope techniques, reveals that some mosasaurs adapted to river systems as seas gradually freshened near the end of the age of dinosaurs. These enormous reptiles, possibly as long as a bus, appear to have hunted near the surface, perhaps even feeding on drowned dinosaurs.

A new genetic mapping strategy reveals how entire networks of genes work together to cause disease, filling in the missing links left by traditional genetic studies. The technique could transform how scientists identify drug targets for complex conditions.

A rare, ultra-long earthquake in Myanmar revealed that mature faults can deliver their full force directly to the surface. The discovery could mean stronger shaking near faults like California’s San Andreas than current models predict.

Researchers discovered a hidden molecular “switch” that herpes viruses rely on to invade cells. By combining AI, simulations, and lab experiments, they identified and altered a single amino acid that shut down viral entry. What once might have taken years was achieved far faster using computational tools. The findings open new possibilities for designing future antiviral treatments.

Hot Jupiters were once cosmic oddities, but unraveling how they moved so close to their stars has remained a stubborn mystery. Scientists have long debated whether these giants were violently flung inward or peacefully drifted through their birth disks. A new approach from researchers in Tokyo cracks open this puzzle by using the timescale of orbital circularization as a diagnostic.

Researchers in Sweden have unveiled a way to create high-performance electronic electrodes using nothing more than visible light and specially designed water-soluble monomers. This gentle, chemical-free approach lets conductive plastics form directly on surfaces ranging from glass to textiles to living skin, enabling surprisingly versatile electronic and medical applications.

Scientists have discovered that key compounds from cannabis—CBD and THC—show surprisingly strong effects against ovarian cancer cells. Used together, they slow cell growth, reduce colony formation, and may even block the cancer’s ability to spread. Even more promising, the treatment caused minimal harm to healthy cells and appears to work by restoring a disrupted signaling pathway that fuels tumor growth.

Male bonobos have an impressive ability to detect when females are most fertile, even though the usual visual cues are unreliable. Researchers tracking wild bonobos in the Congo discovered that males skillfully interpret a mix of swelling timing and a female’s reproductive history to pinpoint the optimal moment for mating. By blending these clues, they overcome nature’s misleading signals and maximize their chances of fathering offspring.

Back pain is wrapped in persistent myths, but many are far from the truth. From misconceptions about heavy lifting and bed rest to confusion over posture, exercise, and surgery, Dr. Meghan Murphy breaks down what really causes pain and what actually helps. Her insights reveal that everyday habits, movement, and smart prevention often make a bigger difference than people realize.

New research shows that your brain’s “true age” can shift dramatically depending on how you live, with optimism, restorative sleep, stress management, and strong social support acting like powerful anti-aging tools. Using advanced MRI-based brain-age estimates, scientists found that people with multiple healthy lifestyle factors had brains up to eight years younger than expected — even among those living with chronic pain.

A series of century-scale droughts may have quietly reshaped one of the world’s earliest urban civilizations. New climate reconstructions show that the Indus Valley Civilization endured repeated long dry periods that gradually pushed its people toward the Indus River as rainfall diminished. These environmental stresses coincided with shrinking cities, shifting settlements, and eventually widespread deurbanization. Rather than a dramatic collapse, the civilization appears to have faded slowly under relentless climate pressure.

Researchers tracking over 63,000 adults found that high-quality, minimally processed plant foods significantly reduce cardiovascular risk. But when those plant foods are ultra-processed, the advantage disappears—and can even backfire. Some ultra-processed plant diets increased risk by 40%. The study urges a shift toward whole, naturally nutrient-rich plant foods.

Scientists found that certain molecules made by gut bacteria travel to the liver and help control how the body uses energy. These molecules change depending on diet, genetics, and shifts in the microbiome. Some even improved insulin response in liver cells when tested in the lab. The findings could open the door to new ways of preventing or managing obesity and diabetes.

Natural killer cells act as the immune system’s rapid-response team, but the stress of anxiety and insomnia may be quietly thinning their ranks. A study of young women in Saudi Arabia found that both conditions were linked to significantly fewer NK cells—especially the circulating types responsible for destroying infected or abnormal cells. As anxiety severity increased, NK cell levels dropped even further, suggesting a stress-driven weakening of immune defenses.

The study reveals how Balanophora plants function despite abandoning photosynthesis and, in some species, sexual reproduction. Their plastid genomes shrank dramatically in a shared ancestor, yet the plastids remain vital. Asexual reproduction appears to have evolved repeatedly, helping the plants survive in isolated, humid forest habitats. The research highlights surprising resilience in these bizarre parasitic species.

Researchers discovered that tanning beds cause widespread, mutation-laden DNA damage across almost all skin, explaining the sharply increased melanoma risk. Single-cell genomic analysis revealed dangerous mutations even in sun-protected regions. Survivors’ stories underscore how early tanning habits have lifelong consequences. The findings push for stricter policies and clear public warnings.

SereNeuro Therapeutics revealed promising results for SN101, a first-in-class iPSC-derived therapy designed to treat chronic osteoarthritis pain while protecting joint tissue. Instead of blocking pain pathways, SN101 uses lab-grown nociceptors that act like sponges, soaking up inflammatory pain factors without sending pain signals. These cells also release regenerative molecules, offering disease-modifying potential that stands apart from traditional corticosteroids and single-target drugs like Nav1.8 inhibitors.